Post by syaoranvee on Dec 5, 2011 4:22:40 GMT -5
Locked up in the bowels of the medical faculty building here and accessible to only a handful of scientists lies a man-made flu virus that could change world history if it were ever set free.
The virus is an H5N1 avian influenza strain that has been genetically altered and is now easily transmissible between ferrets, the animals that most closely mimic the human response to flu. Scientists believe it's likely that the pathogen, if it emerged in nature or were released, would trigger an influenza pandemic, quite possibly with many millions of deaths.
In a 17th floor office in the same building, virologist Ron Fouchier of Erasmus Medical Center calmly explains why his team created what he says is "probably one of the most dangerous viruses you can make"—and why he wants to publish a paper describing how they did it. Fouchier is also bracing for a media storm. After he talked to ScienceInsider yesterday, he had an appointment with an institutional press officer to chart a communication strategy.
Fouchier's paper is one of two studies that have triggered an intense debate about the limits of scientific freedom and that could portend changes in the way U.S. researchers handle so-called dual-use research: studies that have a potential public health benefit but could also be useful for nefarious purposes like biowarfare or bioterrorism.
.......
"I can't think of another pathogenic organism that is as scary as this one," adds Keim, who has worked on anthrax for many years. "I don't think anthrax is scary at all compared to this."
Some scientists say that's reason enough not to do such research. The virus could escape from the lab, or bioterrorists or rogue nations could use the published results to fashion a bioweapon with the potential for mass destruction, they say. "This work should never have been done," says Richard Ebright, a molecular biologist at Rutgers University in Piscataway, New Jersey, and the Howard Hughes Medical Institute who has a strong interest in biosecurity issues.
The research by the Kawaoka and Fouchier teams set out to answer a question that has long puzzled scientists: Does H5N1, which rarely causes human disease, have the potential to trigger a pandemic? The virus has decimated poultry flocks on three continents but has caused fewer than 600 known cases of flu in humans since it emerged in Asia in 1997, although those rare human cases are often fatal. Because the virus spreads very inefficiently between humans it has been unable to set off a chain reaction and circle the globe.
......
After 10 generations, the virus had become "airborne": Healthy ferrets became infected simply by being housed in a cage next to a sick one. The airborne strain had five mutations in two genes, each of which have already been found in nature, Fouchier says; just never all at once in the same strain.
Ferrets aren't humans, but in studies to date, any influenza strain that has been able to pass among ferrets has also been transmissible among humans, and vice versa, says Fouchier: "That could be different this time, but I wouldn't bet any money on it."
The specter of an H5N1 pandemic keeps flu scientists up at night because of the virus's power to kill. Of the known cases so far, more than half were fatal. The real case-fatality rate is probably lower because an unknown number of milder cases are never diagnosed and reported, but scientists agree that the virus is vicious. Based on Fouchier's talk in Malta, New Scientist reported that the strain created by the Rotterdam team is just as lethal to ferrets as the original one.
"These studies are very important," says biodefense and flu expert Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, Twin Cities. The researchers "have the full support of the influenza community," Osterholm says, because there are potential benefits for public health. For instance, the results show that those downplaying the risks of an H5N1 pandemic should think again, he says.
Knowing the exact mutations that make the virus transmissible also enables scientists to look for them in the field and take more aggressive control measures when one or more show up, adds Fouchier. The study also enables researchers to test whether H5N1 vaccines and antiviral drugs would work against the new strain.
news.sciencemag.org/scienceinsider/2011/11/scientists-brace-for-media-storm.html
The virus is an H5N1 avian influenza strain that has been genetically altered and is now easily transmissible between ferrets, the animals that most closely mimic the human response to flu. Scientists believe it's likely that the pathogen, if it emerged in nature or were released, would trigger an influenza pandemic, quite possibly with many millions of deaths.
In a 17th floor office in the same building, virologist Ron Fouchier of Erasmus Medical Center calmly explains why his team created what he says is "probably one of the most dangerous viruses you can make"—and why he wants to publish a paper describing how they did it. Fouchier is also bracing for a media storm. After he talked to ScienceInsider yesterday, he had an appointment with an institutional press officer to chart a communication strategy.
Fouchier's paper is one of two studies that have triggered an intense debate about the limits of scientific freedom and that could portend changes in the way U.S. researchers handle so-called dual-use research: studies that have a potential public health benefit but could also be useful for nefarious purposes like biowarfare or bioterrorism.
.......
"I can't think of another pathogenic organism that is as scary as this one," adds Keim, who has worked on anthrax for many years. "I don't think anthrax is scary at all compared to this."
Some scientists say that's reason enough not to do such research. The virus could escape from the lab, or bioterrorists or rogue nations could use the published results to fashion a bioweapon with the potential for mass destruction, they say. "This work should never have been done," says Richard Ebright, a molecular biologist at Rutgers University in Piscataway, New Jersey, and the Howard Hughes Medical Institute who has a strong interest in biosecurity issues.
The research by the Kawaoka and Fouchier teams set out to answer a question that has long puzzled scientists: Does H5N1, which rarely causes human disease, have the potential to trigger a pandemic? The virus has decimated poultry flocks on three continents but has caused fewer than 600 known cases of flu in humans since it emerged in Asia in 1997, although those rare human cases are often fatal. Because the virus spreads very inefficiently between humans it has been unable to set off a chain reaction and circle the globe.
......
After 10 generations, the virus had become "airborne": Healthy ferrets became infected simply by being housed in a cage next to a sick one. The airborne strain had five mutations in two genes, each of which have already been found in nature, Fouchier says; just never all at once in the same strain.
Ferrets aren't humans, but in studies to date, any influenza strain that has been able to pass among ferrets has also been transmissible among humans, and vice versa, says Fouchier: "That could be different this time, but I wouldn't bet any money on it."
The specter of an H5N1 pandemic keeps flu scientists up at night because of the virus's power to kill. Of the known cases so far, more than half were fatal. The real case-fatality rate is probably lower because an unknown number of milder cases are never diagnosed and reported, but scientists agree that the virus is vicious. Based on Fouchier's talk in Malta, New Scientist reported that the strain created by the Rotterdam team is just as lethal to ferrets as the original one.
"These studies are very important," says biodefense and flu expert Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, Twin Cities. The researchers "have the full support of the influenza community," Osterholm says, because there are potential benefits for public health. For instance, the results show that those downplaying the risks of an H5N1 pandemic should think again, he says.
Knowing the exact mutations that make the virus transmissible also enables scientists to look for them in the field and take more aggressive control measures when one or more show up, adds Fouchier. The study also enables researchers to test whether H5N1 vaccines and antiviral drugs would work against the new strain.
news.sciencemag.org/scienceinsider/2011/11/scientists-brace-for-media-storm.html
Only takes one person to fuck up and it's Stephen King's The Stand up in here.
